HORMONAL INTERACTION IN THE REGULATION OF GRANULATION TISSUE FORMATION
- 1 September 1952
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 51 (3), 183-191
- https://doi.org/10.1210/endo-51-3-183
Abstract
Hormonal influences upon granulation tissue forming around turpentine abscesses of white rats were studied. Cortisone suspended in turpentine inhibited granulation tissue formation locally. Estradiol injn. in the same manner inhibited granulation tissue systemically, unlike cortisone. Methylandrostenediol caused moderate inhibition of granulation tissue. Thyroxine had no effect. DCA injns. systemically counteracted the local inhibitory effect of cortisone, but produced "abnormal" granulation tissue. Growth hormone restituted the cortisone inhibited granulation tissue in hypophysectomized animals to normal. Tissue stimulated by DCA differs from that stimulated by growth hormone. Growth hormone apparently acts upon the same factors as cortisone and is its true antagonist.Keywords
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