Effect of Complete Ureteral Obstruction for One Week on Kidney Function

Abstract

The effects of complete ureteral obstruction for 1 wk. on renal function and the degree and rate of improvement which followed release of the obstruction were evaluated by renal clearance methods in dogs. One hr. after release of the ureter, the clearances of the previously obstructed kidneys were found to be decreased and those of the control side increased. Subsequently, the GFR and ERPF of the right kidney improved and the clearances of the control kidney decreased. Ultimately, the fraction contributed by each kidney became constant. The control kidney of 2 dogs was removed 2 days after the right ureter was released. Under this circumstance the GFR and ERPF of the right kidney improved more promptly and to a greater degree than occurred in the presence of the control kidney.