EFFECTS OF 17-ß-ESTRADIOL AND OF GROWTH HORMONE ON THE PRODUCTION OF ACID MUCOPOLYSACCHARIDES BY HUMAN EMBRYONAL FIBROBLASTS IN VITRO

Abstract

17-[beta]-estradiol added to the medium (0.1 [mu]g/ml and 0.4 [mu]g/ml) of replicate cultures of human embryonal fibroblasts elicited an increase in production of AMPS while depressing the growth rate of the cells. No noticeable effect on growth rate of these cells nor on their AMPS production was exerted by human growth hormone (20 [mu]g/ml and 100 [mu]g/ml).