THE EFFECT OF THE CHRONIC ADMINISTRATION OF ADRENAL MEDULLARY HORMONES TO MAN ON ADRENOCORTICAL FUNCTION AND THE RENAL EXCRETION OF ELECTROLYTES

Abstract

The admn. of epinephrine to normal men in a dosage of from 6 to 9 mg. per day for periods of 3-6 days proved to be no more than a very weak chronic stimulus to adrenocortical activity as estimated by the level of circulating eosinophils and the urinary 17-ketosteroids and formaldehydo-genic steroids. Epinephrine in this dosage resulted in increased urinary excretion of Na, chloride, Ca, and uric acid, and diminished urinary excretion of K.