THE EFFECT OF ALLOXAN ON THE ADRENAL CORTICAL SECRETION
- 1 July 1962
- journal article
- research article
- Published by Bioscientifica in Acta Endocrinologica
- Vol. 40 (3), 349-357
- https://doi.org/10.1530/acta.0.0400349
Abstract
The present study demonstrates that a diabetogenic dose of alloxan produces a rapid and transient increase in the peripheral plasma corticosterone levels. This is attributed to the adrenal response to the stress situation provoked by alloxan. Pre-treatment of the animals with fluorocortisol prevents this adrenal response and the occurrence of alloxan induced hyperglycaemia. The role played by the response of the adrenal cortex on the onset and the maintenance of alloxan diabetes is discussed.Keywords
This publication has 6 references indexed in Scilit:
- Diurnal Rhythm in Plasma Corticosterone and Lack of Diurnal Rhythm in Plasma Compound F-like Material in the Rat.Experimental Biology and Medicine, 1960
- Practical Procedure for Estimation of Corticosterone or HydrocortisoneClinical Chemistry, 1958
- Fluorimetric measurement of adrenocortical steroids in concentrated acid solutionBiochemical Journal, 1958
- PREVENTION OF ADRENAL CORTICAL HYPERTROPHY IN DIABETIC RATS BY THE USE OF INSULIN1Endocrinology, 1955
- THE RÔLE OF THE ADRENAL CORTEX IN DIABETIC KETOSISImmunology & Cell Biology, 1951
- Alloxan Diabetes in Rabbits. Production of Hypercholesterolemia, Hyperlipemia and Adrenal Cortical LesionsExperimental Biology and Medicine, 1945