The 16α-hydroxylation of dehydroepiandrosterone (3β-hydroxyandrost-5-en-17-one) by rat-liver slices
- 1 March 1962
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 82 (3), 390-394
- https://doi.org/10.1042/bj0820390
Abstract
Incubation of dehydroepiandrosterone with liver slices from male rats results in the biosynthesis of a blue-tetrazolium-reducing metabolite which has been isolated and identified as 16[alpha]-hydroxy-dehydroepiandrosterone. Reduced nicotinamide-adenine dinucleotide phosphate has a stimulating effect on this reaction. Little, if any, activity was shown by liver slices from female rats. Castration appears to decrease 16[alpha]-hydroxylating ability without its reaching, however, the low levels of the female.Keywords
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