Disposal of Human Chylomicrons Administered Intravenously in Ischemic Heart Disease and Essential Hyperlipemia

Abstract

Human lymph chylomicrons labeled in vivo with C-14 palmitate were infused into eight patients with ischemic heart disease and into eight control subjects. The mean rates of removal of radioactivity from the chylomicron fraction of the plasmas of these subjects were found to be the same in the two groups. Labeled chylomicrons were also prepared from the blood of six patients with ischemic heart disease and of six controls, and infused into six recipients as paired infusions. Radioactivity from chylomicrons obtained from patients with ischemic heart disease was as readily removed from the circulations of recipients as was radioactivity from chylomicrons obtained from control subjects. When lymph chylomicrons were infused into two patients with hyperlipemia, the rate of removal of chylomicron radioactivity was considerably less than normal and appeared to be related to the levels of endogenous esterified fatty acids.