Incorporation of Cystine and Lysine by Normal and "Cystinuric" Leukocytes

Abstract

Leukocytes of cystinuric patients incorporate labelled cystine and lysine from the medium at a normal rate, even when these amino acids are added in very low concentration (7.1 x 10-6 [image] and .43 x 10-4 [image] respectively). The rate of uptake of cystine by either normal or "cystinuric" leukocytes is not affected by the presence of high concentrations of arginine and lysine (2.5 x 10-3 [image]). The mechanism of renal tubular concentration may therefore be different in kind from that of leukocytes.