Toxicity of Histamine and Dial with Urethane in Intact and Adrenalectomized Hamsters.

Abstract

LD50 of histamine at 4 hours for the unanesthetized male golden hamster was 75 mg/100 g body weight intraperitoneally. Toxicity was increased by the use of dial with urethan as an anesthetic at an hour prior to injection of histamine (LD50 at 4 hours between 20 and 30 mg). Pretreatment with 12 daily doses of 0.3 mg of cortisone reduced the lethal effect of histamine. Susceptibility to histamine poisoning was increased about 10 times in adrenalectomized hamsters without anesthesia, and dial with urethan per se was toxic after adrenalectomy.