Preferential X-chromosome activity in human female placental tissues
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 41 (3), 163-168
- https://doi.org/10.1159/000132221
Abstract
Preferential inactivation of the paternally derived X chromosome in extraembryonic membranes of female rodents has been clearly demonstrated, but the mode of X-chromosome inactivation in the human placenta has not been so clearly defined. We examined A and B variants of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD) in 42 informative placentae to investigate whether the earliest differentiating human female embryonic cells exhibit preferential inactivation of the paternally inherited X. Contamination of villi with fetal blood was eliminated through culture of villous tissues, and maternal cell contamination was eliminated by careful dissection. Both fresh and cultured amnion and chorion, as well as cultured villi, revealed preferential maternal allele expression.Keywords
This publication has 11 references indexed in Scilit:
- Age-dependency of somatic selection in South African Negro G-6-PD heterozygotesHuman Genetics, 1981
- X-chromosome inactivation in extra-embryonic membranes of diploid parthenogenetic mouse embryos demonstrated by differential stainingNature, 1980
- IN SEARCH OF NONRANDOM X-INACTIVATION - STUDIES OF FETAL MEMBRANES HETEROZYGOUS FOR GLUCOSE-6-PHOSPHATE-DEHYDROGENASE1979
- Evidence for selection in cultured diploid fibroblast strainsExperimental Cell Research, 1978
- Origin of mitotic cells of the chorionic villi in direct chromosome analysisHuman Genetics, 1978
- Preferential X inactivation in human placenta membranes: Is the paternal X inactive in early embryonic development of female mammals?Human Genetics, 1978
- Cytologic evidence for preferential inactivation of the paternally derived X chromosome in XX mouse blastocystsCytogenetic and Genome Research, 1978
- Preferential expression of the maternally derived X chromosome in the mouse yolk sacCell, 1977
- Negro Variant of Glucose-6-Phosphate Dehydrogenase Deficiency (A - ) in ManScience, 1967
- Selection in Mammalian Mosaic Cell PopulationsCold Spring Harbor Symposia on Quantitative Biology, 1964