EXPERIMENTAL LIPEMIA AND HYPERCHOLESTEROLEMIA BY PROTEIN DEPLETION AND BY CHOLESTEROL FEEDING IN DOGS

Abstract

Dogs on high-fat (33%) control diet with 25% of casein had some increase in serum total fatty acids but not in cholesterol. Both were increased on the high-fat control diet with added cholesterol and on the high-fat protein-deficient diet with or without cholesterol. The increase of cholesterol was proportionately greater than that of total fatty acids in all 3 groups. Lipemia, fatty liver, decrease of hepatic dye clearance and increase of serum phosphatase were all accompaniments of protein-deficiency and cholesterol feeding, but no definite correlation was demonstrated.