Notizen: Mode of action of O-seryl-N-acetylgalactosaminide glycohydrolase

Abstract
Experiments indicate that the known resistance of natural ovine submaxillary gland glycoprotein to the enzyme results from steric hindrance by the voluminous N-acetylneuraminic acid unit rather than from the negative charge at its carboxyl group. A [beta]-elimination type of reaction as the mechanism of the action of seryl-N-acetylgalactosaminidase can be excluded.