THE RATE OF REMOVAL OF HEMOGLOBIN FROM THE CIRCULATION AND ITS RENAL THRESHOLD IN HUMAN BEINGS

Abstract

20 normal persons received intraven. injns. of varied amts. of human Hb and the curves of disappearance of the Hb from the blood stream as well as the occurrence and amount of hemoglobinuria were noted. There is no constant conc. of Hb in plasma which causes Hburia; but there is a fairly regular relationship of the dosage causing Hburia to body wt. In women Hburia generally occurs with doses of Hb of 72 mg. per kilo or over, in men only with doses of 92 mg. or over. The very rapid removal of Hb from the plasma during the early hrs. after large doses is partly explained by the assumption that the renal tubular epithelium resorbs a large part of the Hb initially filtered through the glomeruli.