Erythropoiesis

Abstract

TNTIL ten or fifteen years ago¹ knowledge of red cell production was based primarily on morphologic observation. During the past decade, however, the introduction and availability of isotopic technics, particularly those permitting labeling of deoxyribonucleic acid (DNA) and hemoglobin, have permitted the rapid accumulation of more quantitative information on the kinetics of red-cell production. At about the same time the work of Reissmann¹ renewed interest in the regulation of erythropoiesis, culminating in Erslev's² demonstration in anemic animals of a humoral substance that stimulates red-cell production. The existence of this plasma factor, erythropoietin, has been confirmed in a number of laboratories . . .