Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder?
- 1 October 1991
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Pain
- Vol. 47 (1), 25-30
- https://doi.org/10.1016/0304-3959(91)90007-k
Abstract
In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder. Both treatments resulted in a statistically significant reduction in pain. However, pain reduction in the combined treatment did not differ from that in the treatment with amitriptyline as a single drug. Neither tardive dyskinesias nor other serious side effects were observed. The results do not support the clinical practice of adding low-dose neuroleptics to low-dose antidepressants in the treatment of somatoform pain disorder.Keywords
This publication has 11 references indexed in Scilit:
- Low dose amitriptyline in chronic pain: The gain is modestPain, 1990
- Chlorprothixene (taractan) in post-herpetic neuralgia and other severe chronic painsPain, 1978
- Ergebnisse psychopharmakologischer SchmerzbehandlungPharmacopsychiatry, 1978
- Peripheral diabetic neuropathy treated with amitriptyline and fluphenazinePublished by American Medical Association (AMA) ,1977
- Die Behandlung chronischer Schmerzzustände mit PsychopharmakaPharmacopsychiatry, 1976
- Chlorprothixene Therapy for Herpes Zoster NeuralgiaSouthern Medical Journal, 1974
- Relief of postherpetic neuralgia with psychotropic drugsJournal of Neurosurgery, 1973
- The treatment of chronic pain with psychotropic drugsPublished by Oxford University Press (OUP) ,1972
- A RATING SCALE FOR EXTRAPYRAMIDAL SIDE EFFECTSActa Psychiatrica Scandinavica, 1970
- Development of a Rating Scale for Primary Depressive IllnessBritish Journal of Social and Clinical Psychology, 1967