Increasing and Prolonging Blood Penicillin Concentrations Following Intramuscular Administration
- 29 June 1945
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 101 (2635), 673-674
- https://doi.org/10.1126/science.101.2635.673
Abstract
(1) Restriction of fluid intake to 1,500 cc and the salt intake to 3 gm a day doubles the penicillin blood level following interrupted intramuscular [See Figure in the PDF file] injections of penicillin. (2) The administration of benzoic acid to a patient on an unrestricted diet Ilay double the penicillin blood level during similar treatment. (3) The combination of these two procedures results in a four- to eight-fold increase in penicillin blood level with a prolonged effective blood concentration.This publication has 11 references indexed in Scilit:
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