OXYGEN INHIBITION OF GROWTH OF MYCOBACTERIUM TUBERCULOSIS
- 1 April 1964
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 87 (4), 838-+
- https://doi.org/10.1128/jb.87.4.838-843.1964
Abstract
By continuous or intermittent exposure to 3 atm. of oxygen in the presence or absence of 40 mm of Hg, CO2 resulted in marked delay or inhibition of growth of Mycobacterium tuberculosis. This inhibition was more pronounced with newly inoculated cultures, as compared to young, actively growing cultures. Oxygen inhibition of growth was observed on both Lowenstein-Jensen and blood agar media. Bacteriostatic effects of oxygen are a direct function of exposure time. A more marked effect of oxygen was observed in the presence of isoniazid, streptomycin or p-amino-salicyclic-acid.Keywords
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