Distribution of thiocyanate between plasma and cerebrospinal fluid

Abstract

Relatively small amounts of thiocyanate are found in the cerebrospinal fluid (CSF) at plasma levels below 1 mm/liter. Starting at plasma concentrations of about 1.5 mm/liter, a relatively constant plasma-CSF differential of approximately 1.2 mm/liter is established and maintained. This concentration difference, which essentially represents the "blood-CSF barrier" to thiocyanate is reversibly reduced by the intracisternal administration of hypertonic solutions.