EFFECT OF VITAMIN B 12 DERIVATIVES ON OXIDATION AND VITAMIN UPTAKE BY ESCHERICHIA COLI
- 1 February 1953
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 65 (2), 183-186
- https://doi.org/10.1128/jb.65.2.183-186.1953
Abstract
Vitamin Bl2a, benzimidazole, 2,5-dimethylbenzimidazole, 5-6-dimethylbenzimidazole, and a-ribazole were tested for vitamin B12-like stimulation of the acetate oxidation system of a mutant strain of E. coli requiring vitamin B12 for growth. Only vitamin B12a was found to exhibit such activity. When these compounds were tested for the ability to prevent vitamin B12 stimulation, only 5,6-dimethylbenzimidazole was effective as an inhibitor. This compound interfered with the uptake of radioactive vitamin B12 by cells grown with the vitamin, but did not affect the uptake by cells grown with methionine.Keywords
This publication has 10 references indexed in Scilit:
- Growth Response and Vitamin B12 Tissue Levels in Vitamin B12-Deficient Rats and Chicks Fed Riboflavin, 5,6-Dimethylbenzimidazole and Related CompoundsJournal of Nutrition, 1952
- Uptake of vitamin B12 by Escherichia coliArchives of Biochemistry and Biophysics, 1952
- THE EFFECT OF 5,6-DIMETHYLBENZIMIDAZOLE AND RELATED COMPOUNDS ON THE GROWTH OF LACTOBACILLUS LACTIS DORNERJournal of Bacteriology, 1951
- THE INFLUENCE OF VITAMIN B 12 ON OXIDATION BY A MUTANT STRAIN OF ESCHERICHIA COLIJournal of Bacteriology, 1951
- Vitamin B12. XII. Vitamin B12-like Activity of α- and β-RibazoleJournal of the American Chemical Society, 1951
- Vitamin B12: Reactions of Cyano-Cobalamin and Related CompoundsScience, 1950
- Vitamin B12. VIII. Vitamin B12-Like Activity of 5,6-Dimethylbenzimidazole and Tests on Related CompoundsJournal of the American Chemical Society, 1950
- MUTANTS OF ESCHERICHIA COLI REQUIRING METHIONINE OR VITAMIN B 12Journal of Bacteriology, 1950
- VITAMIN B12. IX. 1-α-D-RIBOFURANOSIDO-5,6-DIMETHYLBENZIMIDAZOLE, A DEGRADATION PRODUCT OF VITAMIN B12Journal of the American Chemical Society, 1950
- VITAMIN B12. VI. 5,6-DIMETHYLBENZIMIDAZOLE, A DEGRADATION PRODUCT OF VITAMIN B12Journal of the American Chemical Society, 1949