EFFECT OF PROSTAGLANDIN‐INHIBITOR NAPROXEN ON THE CORNEAL SWELLING RESPONSE TO HYDROGEL CONTACT LENS WEAR

Abstract

Previous studies have demonstrated that the progstaglandin-inhibitor naproxen can reduce postsurgical corneal edema, which is largely due to an inflammatory process. To determine whether ther is an inflammatory component in the edematous response of the cornea to contact lens wear, a randomized, double-masked, placebo-controlled study was conducted on the effect of naproxen on contact lens-induced corneal swelling. This drug did not have a significant effect, suggesting tht prostaglandins are not involved in the hypoxic edema response. The discrepancy between the effect of naproxen on lens- and surgically-induced corneal edema can be attributed to the different aetiologies of these edema responses.