Parathymosin alpha: a peptide from rat tissues with structural homology to prothymosin alpha.
Open Access
- 1 February 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (4), 1050-1053
- https://doi.org/10.1073/pnas.82.4.1050
Abstract
A peptide, parathymosin .alpha., containing .simeq. 105 amino acid residues, was isolated from rat thymus, and the sequence of the first 30 residues at the NH2 terminus was determined. In this region, it shows 43% structural identity with thymosin .alpha.1 and prothymosin .alpha.. The common sequences do not include residues 2-9, which accounts for the poor reactivity of parathymosin .alpha. with an antibody directed against this epitope in thymosin .alpha.1. Parathymosin .alpha. appears to modulate the action of prothymosin .alpha. in protecting sensitive strains of mice against opportunistic infection with Candida albicans.This publication has 9 references indexed in Scilit:
- Primary structure of rat thymus prothymosin alpha.Proceedings of the National Academy of Sciences, 1985
- Distribution of prothymosin alpha in rat tissues.Proceedings of the National Academy of Sciences, 1984
- Cytosolic Ca2+-dependent neutral proteinases from rabbit liver: activation of the proenzymes by Ca2+ and substrate.Proceedings of the National Academy of Sciences, 1984
- Thymosin alpha 11: a peptide related to thymosin alpha 1 isolated from calf thymosin fraction 5.Proceedings of the National Academy of Sciences, 1983
- Thymosin β10, a new analog of thymosin β4 in mammalian tissuesArchives of Biochemistry and Biophysics, 1983
- Resistance and susceptibility to infection in inbred murine strainsCellular Immunology, 1983
- Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1.The Journal of Immunology, 1982
- The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.Journal of Biological Chemistry, 1979
- Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.Proceedings of the National Academy of Sciences, 1977