Acid Sensitivity of Glycolysis in Normal and Proton-permeable Cells of Streptococcus mutans GS-5
- 1 November 1983
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 62 (11), 1174-1178
- https://doi.org/10.1177/00220345830620111701
Abstract
Gramicidin, an ionophoric antibiotic which enhances proton permeability of cell membranes, was found to increase the acid sensitivity of glycolysis by intact cells of Streptococcus mutans GS-5, to inhibit uptake of 2-deoxyglucose at pH values of 5.5 or less, and to cause a decrease in the intracellular levels of early intermediates of glycolysis. The inhibitory effects of the antibiotic on glycolysis at low pH values were related to inhibition of sugar uptake via the phosphotransferase system.Keywords
This publication has 18 references indexed in Scilit:
- Properties of Streptococcus mutans Ingbritt growing on limiting sucrose in a chemostat: repression of the phosphoenolpyruvate phosphotransferase transport systemInfection and Immunity, 1982
- Evidence for the Involvement of Proton Motive Force in the Transport of Glucose by a Mutant of Streptococcus mutans Strain DR0001 Defective in Glucose-Phosphoenolpyruvate Phosphotransferase ActivityInfection and Immunity, 1982
- pH homesstasis in bacteriaBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1981
- Enolases from fluoride-sensitive and fluoride-resistant streptococciInfection and Immunity, 1981
- Enhanced transmembrane proton conductance in Streptococcus mutans GS-5 due to ionophores and fluorideAntimicrobial Agents and Chemotherapy, 1981
- Rate-limiting steps of the glycolytic pathway in the oral bacteria Streptococcus mutans and Streptococcus sanguis and the influence of acidic pH on the glucose metabolismArchives of Oral Biology, 1980
- Circulation of H + and K + Across the Plasma Membrane Is Not Obligatory for Bacterial GrowthScience, 1977
- Effect of Sugar Analogues on Growth, Sugar Utilization, and Acid Production by Streptococcus mutansJournal of Dental Research, 1975
- Phosphoenolpyruvate-Dependent Glucose Transport in Oral StreptococciJournal of Dental Research, 1973
- Studies on Erythrocyte Glycolysis I. Determination of the Glycolytic Intermediates in Human Erythrocytes*The Journal of Biochemistry, 1965