Karyotype evolution in the bone marrow of a patient with Fanconi anemia: breakpoints in clonal anomalies of this disease
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 48 (4), 224-227
- https://doi.org/10.1159/000132633
Abstract
A 21-year-old Fanconi anemia patient developed refractory anemia. Laboratory studies revealed a transitory increased platelet count and a typical del(5q). Bone marrow karyo-typing showed a -6, + der(6)t(1;6)(q12;p25) rearrangement and, two years later, a mosaic-6,-1-der(6), t(1:6)(q12;p25)/-2, +der 2), t(l;2)(q12;q37) constitution. The chromosome mechanism operating in this patient is discussed.Keywords
This publication has 8 references indexed in Scilit:
- Multiple telomeric associations of a trisomic whole q arm of chromosome 1 in a child with acute lymphoblastic leukemiaCancer Genetics and Cytogenetics, 1987
- Fluctuation of a clone 46,XX,i(7q) in bone marrow in a Fanconi anaemiaHuman Genetics, 1986
- Telomeric association of chromosomes in B-cell lymphoid leukemiaHuman Genetics, 1984
- BURKITTS-LYMPHOMA IN AIDS - CYTOGENETIC STUDY1984
- Telomere regions in drosophila share complex DNA sequences with pericentric heterochromatinCell, 1983
- Chromosomal studies of leukemic and preleukemic Fanconi's anemia patientsHuman Genetics, 1980
- Application of chromosome banding techniques to the study of primary chromosome structural changes.Journal of Medical Genetics, 1977
- Somatic segregation and Fanconi anemiaClinical Genetics, 1977