Influence of anti-mouse interferon serum on the growth and metastasis of tumor cells persistently infected with virus and of human prostatic tumors in athymic nude mice
- 1 February 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (2), 1171-1175
- https://doi.org/10.1073/pnas.78.2.1171
Abstract
Baby hamster kidney or HeLa cells form tumors in 100% of athymic nude mice. When such cells are persistently infected (PI) with RNA viruses, such as mumps or measles virus, the tumor cells either fail to grow or form circumscribed benign nodules. Neither the parental nor the virus PI tumor cells form invasive or metastatic lesions in nude mice. Previous studies have indicated a correlation between the susceptibility of virus-PI tumor cells in vitro and the cytolytic activity of natural killer (NK) cells and their failure to grow in vivo. Because interferon (IF) is the principal regulatory molecule governing the differentiation of NK cells, it was possible to test the relevance of the IF-NK cell system in vivo to restriction of tumor growth by treatment of nude mice with anti-IF globulin. This treatment was shown to reduce both IF production and NK activity in spleen cells. Both parental and virus-PI tumor cells grew and formed larger tumors in nude mice treated with anti-IF globulin than in control nude mice. The viral-PI tumor cells and the uninfected parental cells formed tumors in treated mice that were highly invasive and often metastatic. Some human tumor types have been notoriously difficult to establish as tumor lines in nude mice (e.g., primary human prostatic carcinomas). When transplanted into nude mice treated either with anti-IF globulin or anti-lymphocyte serum, two prostatic carcinomas grew and produced neoplasms with local invasiveness and some metastases. The results are consistent with the view that interferon may be important in restricting the growth, invasiveness, and metastases of tumor cells by acting indirectly through components of the immune system, such as NK cells.Keywords
This publication has 27 references indexed in Scilit:
- Mode of regulation of natural killer cell activity by interferonThe Journal of Experimental Medicine, 1980
- Identification of the cell multiplication inhibitory factors in interferon preparations as interferonsNature, 1976
- Biology of the human malignant lymphomasIII. Intracranial heterotransplantation in the nude, athymic mouseCancer, 1976
- Brief Communication: Growth of Human Normal and Neoplastic Mammary Tissues in the Cleared Mammary Fat Pad of the Nude Mouse2JNCI Journal of the National Cancer Institute, 1975
- Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificityInternational Journal of Cancer, 1975
- Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid mediumCell, 1974
- Metastases of Human Melanomas Transplanted in “Nude” Mice2JNCI Journal of the National Cancer Institute, 1973
- Mechanism of the Antitumour Effect of Interferon in MiceNature, 1972
- Interferon and Cell Division VI. Inhibitory Effect of Interferon on the Multiplication of Mouse Embryo and Mouse Kidney Cells in Primary CulturesExperimental Biology and Medicine, 1971
- INTERFERON AND CELL DIVISION, I. INHIBITION OF THE MULTIPLICATION OF MOUSE LEUKEMIA L 1210 CELLS In Vitro BY INTERFERON PREPARATIONSProceedings of the National Academy of Sciences, 1970