Folic Acid Antagonists

Abstract
Folic acid antagonists are dealt with solely from the standpoint of their activity in animals. The review does not cover their activity in microorganisms. There are 8 subheadings, namely-I. Chemistry of Folic Acid Compounds and of Folic Acid Antagonists, II. General Aspects of Toxicity of Folic Acid Antagonists, HI. Reversibility of Folic Acid Antagonists, IV. Hematologic Effects of Folic Acid Antagonists, V. Hormonal Interaction of Folic Acid Antagonists, VI. Relationship of Folic Acid Antagonists to Enzyme Action, VII. Effect of Folic Acid Antagonists on Neoplasia, and vm. Mechanisms of Action of Folic Acid Antagonists.