Estimations of Cardiac Output and Central Blood Volume by Dye Dilution

Abstract

This review is chiefly concerned with the more recent contributions which fall into four categories: (1) modifications, improvements, and innovations in method, such as the use of other indicators than dye and the development of new apparatus, especially various ways of recording arterial concentrations continuously; (2) experimental applications of the method, leading to further validation or criticism, or to the enlargement of physiological or clinical knowledge; (3) attempts to reach an understanding of the arterial time-concentration curve, upon either a rational, a stochastic, or an empiric basis; (4) treatments-often polemic-of a few recurrently controversial topics, such as the proper use of the dilution curve as an index of volume as well as flow, and the relative merits of [image]slug[image] injection or continuous infusion.