Secretion of the Hyperglycemic-Glycogenolytic Factor in Normal Dogs

Abstract

Cross-circulation expts. anastomosing the pancreato-duodenal vein of a donor dog D with a femoral vein of a receipient dog R showed that the injn. of insulin in dog D was followed by hyperglycemia in dog R, suggesting that the pancreas of dog D secreted hyperglycemic factor (HGF) in response to insulin hypoglycemia. The injn. of HGF into dog D was followed by hypoglycemia in dog R suggesting that the pancreas of dog D secreted insulin in response to HGF hyperglycemia. It is suggested that HGF is a 2d pancreatic hormone and that its secretion, like that of insulin, is regulated by the blood sugar concn.