Inhibition of Isoniazid Acetylation in vitro and in vivo.
- 1 June 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 92 (2), 446-448
- https://doi.org/10.3181/00379727-92-22505
Abstract
The acetylation of isoniazid by pigeon liver extracts is inhibited by various aromatic amino, amido, and hydrazino compounds. p-Aminosalicylic acid, given in conjunction with isoniazid to rabbits, produced a marked increase in the plasma level of free isoniazid. A similar effect was obtained with sulfanilamide. A colorimetric method for the determination of free isoniazid in the presence of aromatic amines is described.Keywords
This publication has 5 references indexed in Scilit:
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- THE INHIBITION OF SULPHANILAMIDE ACETYLATION BY AROMATIC AND HETEROCYCLIC CARBOXAMIDES AND CARBOXHYDRAZIDESCanadian Journal of Biochemistry and Physiology, 1955
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- CHEMOTHERAPY OF EXPERIMENTAL TUBERCULOSIS .5. ISONICOTINIC ACID HYDRAZIDE (NYDRAZID) AND RELATED COMPOUNDSPublished by Elsevier ,1952