CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XVI. FIBRIN CLOTS, FIBRIN FILMS, AND FIBRINOGEN PLASTICS 12

Abstract

Fibrin clots, fibrin films, and fibrinogen plastics are structural materials derived from the proteins of human plasma involved in the natural coagulation process. The clots can be prepared with a wide range of properties, grading from a type which is transparent, gelatinous, friable, adherent, and nonsynerizing to a type which is opaque, doughy, non-adherent, and syner-izing. The films consist of fibrin and plasticizer and their properties depend upon the proportions of these components. Their stress-strain curves can simulate those of natural anatomical structures. Their resistance to proteo-lytic enzymes can be altered by suitable treatment. The plastics can be prepared with rubbery, leathery, or horny characteristics. All the products can be made in various shapes. Methods for large-scale sterilization have not yet been devised.