Partial Activation of Purified Prothrombin: Derivation of Autoprothrombin I with Use of Autoprothrombin C

Abstract

Activation of purified prothrombin with autoprothrombin C in the absence of calcium ions produces autoprothrombin I activity. The solubility, and stability properties of this autoprothrombin I are different from those of autoprothrombin I when obtained by activating prothrombin with calcium ions, platelet factor 3, and Ac-globulin. ^* This investigation was supported by a research grant H-3424 from the National Heart Institute, National Institutes of Health, U.S. Public Health Service. ^** The Rockefeller Foundation, Research Fellow.