Question of an Inhibitory Hormone From the Gastric Antrum

Abstract

Acid applied to the antrum mucosa in dogs inhibits the gastric phase of gastric secretion as exhibited in the vagus denervated Heidenhain pouch. To determine if this inhibition of secretion is due to failure of formation or release of gastrin from the antrum, or to the liberation of an inhibitory hormone from the gastric antrum which acts on the parietal cells, dogs were prepared with an isolated Heidenhain pouch and two pouches prepared from the gastric antrum. These antrum pouches were prepared with vagus innervation intact and with vagus innervation eliminated. Gastric secretion in the Heidenhain pouch elicited by the introduction of liver solution or acetylcholine into one of the antrum pouches was not inhibited by the introduction of acid into the second antrum pouch. These data suggest that acid in contact with the antrum mucosa prevents the formation or release of gastrin and does not release an inhibitory hormone.