Failure of the Liver of the Monkey to Inactivate Estrogens in vivo.
- 31 May 1947
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 65 (2), 192-194
- https://doi.org/10.3181/00379727-65-15906
Abstract
Intrasplenic implantation of pellets of estrone and estradiol in 4 ovariecto-mized rhesus monkeys was followed by reddening of the sex skin and alteration of the vaginal smear as promptly and with the same intensity as in a control animal given estradiol benzoate intramusc. Endometrial changes were alike, and removal of the intrasplenic pellet was followed by typical estrogen-deprivation menstruation. Liver function tests revealed no hepatic damage, and admn. of B vits. did not reduce the actions of the intrasplenic estrogens.Keywords
This publication has 10 references indexed in Scilit:
- Excretion of Estrogen After the Injection of Estradiol and Estrone into Men with Cirrhosis of the LiverJournal of Clinical Endocrinology & Metabolism, 1944
- THE INTRASPLENIC INJECTION OF ESTROGENS AND THEIR ESTERSEndocrinology, 1943
- Studies on the Nutritional Requirements of the Rhesus MonkeyJournal of Nutrition, 1943
- EXCRETION OF ESTROGEN IN BILE1Endocrinology, 1942
- EFFECT OF VITAMIN B COMPLEX DEFICIENCY ON INACTIVATION OF ESTRONE IN THE LIVEREndocrinology, 1942
- THE INACTIVATION OF ESTRADIOL AND ESTRADIOL BENZOATE IN CASTRATE FEMALE RATSEndocrinology, 1941
- LIVER DAMAGE AND ESTROGEN INACTIVATION*Endocrinology, 1940
- SEX HORMONE CHANGES ASSOCIATED WITH LIVER DISEASE1Endocrinology, 1940
- METABOLISM OF THE ESTROGENS THE EFFECT OF LIVER AND UTERUS UPON ESTRONE, ESTRADIOL AND ESTRIOL1,2,3Endocrinology, 1940
- THE INACTIVATION OF ESTROGEN BY THE LIVERThe American Journal of the Medical Sciences, 1937