Conduction block of peripheral nerve using high‐frequency alternating currents delivered through an intrafascicular electrode

Abstract

Many diseases are characterized by undesired or pathological neural activity. The local delivery of high‐frequency currents has been shown to be an effective method for blocking neural conduction in peripheral nerves and may provide a therapy for these conditions. To date, all studies of high‐frequency conduction block have utilized extraneural (cuff) electrodes to achieve conduction block. In this study we show that high‐frequency conduction block is feasible using intrafascicular electrodes. Muscle Nerve, 2010