Physico-Chemical Properties of Blood following Exposure to Methylglucamine Iodipamide, and other Contrast Media

Abstract

Simultaneous development of increased intravascular red blood cell aggregation and a marked decrease in erythrocyte sedimentation rate following iodipamide administration was studied by measurements of certain physico-chemical properties of blood, including viscosity, density, plasma hemoglobin, red blood cell size, shape, packing rate and charge and serum protein electrophoresis. Pertinent results include slight increase in plasma viscosity and density, large increases in whole blood and apparent red blood cell viscosity, decreased red blood cell diameter associated with crenation and spherocytosis, difficulties in the packing of the erythrocytes, and inconstant, but occasionally great, hemolysis.