Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds
- 1 October 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (10), 1035-1044
- https://doi.org/10.1021/jm00208a007
Abstract
Acetic acid derivatives of tricyclic systems, such as 6,11-dihydro-11-oxodibenzo[b,e]thiepin, 4,10-dihydro-4-oxothieno[2,3-c] [1]benzothiepin, dibenzo[b,f]thiepin, dibenz[b,f]oxepin, etc., were synthesized and assayed for anti-inflammatory activity. 6,11-Dihydro-11-oxodibenzo[b,e]thiepin-3-acetic acid, was chosen for evaluation in man on the basis of high antiinflammatory activity in short and long-term animal assays and a low gastric irritation liability in rats and dogs.This publication has 9 references indexed in Scilit:
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