HLA‐DR RFLP distributions in two groups of Aboriginal Australians
- 1 December 1990
- journal article
- Published by Wiley in Australian and New Zealand Journal of Medicine
- Vol. 20 (6), 790-793
- https://doi.org/10.1111/j.1445-5994.1990.tb00424.x
Abstract
HLA-DR and -DQ typing by restriction fragment length polymorphism (RFLP) in Aboriginal Australians from the Kimberleys and from Coen shows a restricted number of HLA-DR types in these populations. The polymorphism is essentially limited to DR2, DR4, DRw14 and DRw8. The most common DR.DQ RFLP haplotype in Aborigines shows a novel arrangement of DR and DQ alleles that has important implications for histocompatibility matching if the RFLP patterns reflect functional variation in HLA class II molecules.Keywords
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