THE EXCRETION OF 17-KETOSTEROIDS, 11-OXYCORTICOSTEROIDS AND “11-DESOXYCORTICOSTEROIDS” IN PATIENTS WITH BRONCHIAL Asthma

Abstract

The daily excretion of 17-ketosteroids, 11-oxycorticosteroids and "11-desoxycorticosteroids" was measured in 10 healthy subjects and in 22 patients with bronchial asthma of different severity and duration, and the ratio of 11-oxycorticosteroids to "11-desoxycorticosteroids" (11-oxy/11-desoxy) was calculated. The amt. of 17-ketosteroids excreted by patients with bronchial asthma was normal. In patients with bronchial asthma of marked severity and long duration there was found a decrease in the excretion of 11-oxycorticosteroids and a relative increase in the excretion of "11-desoxycorticosteroids" when compared with healthy subjects. The ratio between 11-oxycorticosteroids and "11-desoxycorticosteroids" in these patients, by statistical analysis, was significantly decreased.