THE EXCRETION OF 17-KETOSTEROIDS, 11-OXYCORTICOSTEROIDS AND “11-DESOXYCORTICOSTEROIDS” IN PATIENTS WITH BRONCHIAL Asthma
- 1 December 1950
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 10 (12), 1570-1578
- https://doi.org/10.1210/jcem-10-12-1570
Abstract
The daily excretion of 17-ketosteroids, 11-oxycorticosteroids and "11-desoxycorticosteroids" was measured in 10 healthy subjects and in 22 patients with bronchial asthma of different severity and duration, and the ratio of 11-oxycorticosteroids to "11-desoxycorticosteroids" (11-oxy/11-desoxy) was calculated. The amt. of 17-ketosteroids excreted by patients with bronchial asthma was normal. In patients with bronchial asthma of marked severity and long duration there was found a decrease in the excretion of 11-oxycorticosteroids and a relative increase in the excretion of "11-desoxycorticosteroids" when compared with healthy subjects. The ratio between 11-oxycorticosteroids and "11-desoxycorticosteroids" in these patients, by statistical analysis, was significantly decreased.Keywords
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