Carbohydrate Metabolism in Experimental Salicylism.

Abstract

Fasting male white rats were given 75 mg/100 g sodium salicylate with or without treatment with 10 mg/100 g Compound F alcohol. Such animals failed to deposit liver glycogen even under the influence of Compound F. N balance were more strongly negative in animals receiving 75 mg/100 g sodium salicylate, Compound F, or both than in untreated controls. The level of muscle glycogen in animals treated with salicylate was markedly reduced, but this effect could be prevented by concurrent treatment with Compound F. Failure of salicylate treated rats to deposit liver glycogen cannot be due to a lack of precursors from body protein but rather to their following other metabolic pathways, possibly conversion to fat and to blood glucose. The muscle glycogen changes are interpreted as a part of an increased rate of utilization of carbohydrate by the peripheral tissues under the influence of large doses of salicylate.